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Amiloride and high blood pressure

Amiloride in hypertension

Amiloride belongs to the group of potassium-sparing diuretics. It is a pyrazine derivative from the guanidino group.

The active ingredient is sold under the drug name Midamor Moduretic and it can be found in pharmacies.

A number of combination products also contain this substance as one of the ingredients.

These are known as Amiloretik, Comilorid, Diaphal, Diursan, Ecodurex, Escoretic, Cold, Loradur, Moducrin, Moduretic, Rhefluin and Tensoflux.

The combination with another diuretic from another group of substances is usually necessary because the active ingredient alone only produces a moderate effect. It is very common to combine it with hydrochlorothiazide.

For the treatment of high blood pressure (hypertension), other dewatering diuretics are used. They expand the vessels, causing the blood pressure to lower.

The diuretic amiloride

Solutions for high blood pressure - amiloride

Amiloride is prescribed for high blood pressure

Above a certain dose amiloride also increases the excretion of salt (sodium chloride) in the urine.

In addition, it increases the volume of urine and thereby deprives the body of liquid. The lower liquid volume in turn regulates the blood pressure.

Potassium-sparing diuretics are characterized to drain without the body to lose potassium.

As well as the mode of action of amiloride. Amiloride inhibits the absorption of sodium by blocking sodium channels in the collecting ducts of the kidney.

To compensate for the increased sodium concentration in the urine, urine volume and water excretion are increased.

The sodium ions are excreted in high concentration in the urine, however, potassium ions are retained.

However, the sodium absorption is only reduced by 2-3%. The effectiveness as a diuretic is therefore low.

For the treatment of high blood pressure and other diseases, therefore combining the active ingredient with loop diuretics or thiazides enhances the diuretic effect.

The amiloride of the task here is to prevent potassium deficiency.

Side effects of amiloride

A possible side effect of all potassium-sparing diuretics is hyperkalaemia, which is too high a potassium concentration in the blood. Hyperkalaemia is a potentially lethal condition and urgently needs to be avoided. Optionally, the potassium intake must be limited in the diet in order to prevent adverse interactions of diuretics that may occur with all drugs that act on the renin-angiotensin-aldosterone system (RAAS).

This group includes several products, which are used to treat hypertension, both beta-blockers and ACE inhibitors.

Therefore caution is advised in the treatment of high blood pressure: If taken as parallel potassium-sparing diuretics with beta-blockers or ACE inhibitors, it can increase the risk of hyperkalaemia.

These drugs are often combined in the treatment of hypertension, so close monitoring of potassium levels in the blood is a must.

Here you can read more about the use of diuretics for high blood pressure and chlorthalidone.




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