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Amlodipine - A calcium channel blocker for high blood pressure

Amlodipine - A good remedy for high blood pressure

The active ingredient amlodipine is used for the treatment of high blood pressure (hypertension), as well as for the treatment of other diseases. These include, heart diseases where there is insufficient oxygen supplied to the heart muscle.

An example of this is angina. Amlodipine is used for both the treatment of the chronic form of angina pectoris and also for the treatment of the spastic form, where there are strong spasms of the coronary arteries and in turn there is a reduced blood flow to the heart that causes pain.

In these diseases, the drug is used to prevent seizures.

Mode of action of amlodipine

Calcium antagonist amlodipine is used for high blood pressure

As a calcium channel antagonist of the dihydropyridine type, amlodipine blocks the L-type calcium channel. This is done by binding to the α1 subunit. This leads to a reduced calcium influx into the muscle cells, so that the muscle tone is reduced.

That reduces the contractility (inotropic negative) as well as the oxygen consumption of cardiac muscle cells.

Unlike the calcium channel antagonist of the verapamil type, dihydropyridines ensure vascular selectivity.

This will ensure that a cardiac action only occurs at high doses for the vasodilation (vascular dilation). In the normal dosage, the active ingredient amlodipine acts mainly on the coronary vessels and the external resistance vessels.

Amlodipine is also a FIASMA (functional inhibitors of acid sphingomyelinase). If you use this drug your blood pressure will go down.

Side effects of the drug Amiopidin

The side effects of this drug are similar to those of other calcium antagonists. It may, for example, cause edema of the legs.

Especially at the beginning of treatment, headaches and facial flushing with a sensation of head can occur.

Furthermore, fatigue, dizziness, palpitations of the heart, abdominal pain and nausea can happen. Every now and then, vomiting may occur. In very rare cases, allergic reactions are possible.

There are now several manufacturers using Amiopidin as an active ingredient in medicines for high blood pressure (hypertension) to regulate the blood pressure. Manufacturers such as Amiud or STADApharm believe that this drug is an excellent remedy for high blood pressure (hypertension). In any case Amiopidin is a good way to lower blood pressure.

Corresponding complications can be avoided and in turn that helps your body to regain good health.

Here you can read more about the calcium antagonist clevidipine and its application in high blood pressure.




Mode of action of amlodipine for hypertension




Side effects of the drug amiopidin




Various types of calcium channel blockers

In general there are 2 different types of calcium antagonists (calcium channel blockers), namely the non-dihydropyridine and the dihydropyridines.

Non-dihydropyridines are:

- diltiazem
- gallopamil
- verapamil

Dihydropyridines are:

- Amlodipine
- Clevidipine
- Felodipine
- Isradipine
- Lacidipine
- Lercanidipine
- Manidipine
- Nicardipine
- Nifedipine
- Nilvadipine
- Nimodipine
- Nisoldipine
- Nitrendipine




What kind of drugs for treating high blood pressure?