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The various beta blockers for high blood pressure

Beta-blockers, in contrast to the alpha-blocker, have a great similarity in the structure of the ß-sympathomimetic.

Therefore, the agonist effects of some beta-blockers come from the beta-receptors.

This feature is called partial agonist activity (PAA) or intrinsic sympathomimetic activity (ISA) and is in most cases undesirable.

Some beta-blockers also feature vasodilating (vasodilator) properties.

For example, Carvedilol causes the blockade of ß1-adrenergic receptor and Celiprolol causes activation at the ß2-adrenoceptor.

ß1-beta-blockers (without ISA) include the active ingredients Atenolol, Betaxolol, Bisoprolol, Esmolol,  Metoprolol and Nebivolol,

The agents with ISA are Acebutolol and Celiprolol.

The non-selective beta-blockers (without ISA), include Carvedilol, Propranolol and Timolol

The agents Carteolol and Pindolol are among the non-selective receptor blockers with ISA

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Beta blockers and their effects on high blood pressure

For hypertension - beta blockers achieve good results
Beta blockers in hypertension

The active substances are manufactured synthetically.

The mechanism of action of beta-blockers in hypertension

Since the activating effect of norepinephrine and epinephrine is inhibited ß-adrenoceptors by beta blockers, there is an attenuation of the stimulatory effect of the sympathetic nervous system to the intended target organs (preferably the heart).

Here, ß 2-adrenoceptor types play an important role: the blood pressure is reduced.

In contrast the excitation of the ß2-adrenergic receptors on the uterus, the bronchial smooth muscle and blood vessels.

The tone of the bronchial muscle is increased and the result can be muscle cramps.

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Beta blockers are the first choice for hypertension

Receptor blockers are combined in the treatment of arterial hypertension in drug therapy, often with other antihypertensive agents.

Since 2008, beta blockers are usually the first choice for high blood pressure, because they also help with heart failure and heart disease.

However, they have a negative effect of unwanted weight gain.

Therefore, patients should avoid taking them with metabolic syndromes (e.g. high plasma glucose levels and impaired glucose tolerance).

Although the efficacy of beta blockers in lowering the blood pressure is undisputed, it is still not clear how the blood pressure reduction is achieved.

The reduction of renin release plays a role.

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The main beta blockers for high blood pressure

Atenolol - Bisoprolol - beta blockers in hypertension
Beta blocker in hypertension

The active ingredient Atenolol causes a permanent adjustment of blood pressure through a complex system, which is based on different nerve signals and messengers.

It belongs to the beta-adrenergic receptor blockers and reduces the influence of adrenaline on the heart by the beta-receptors.

However, the drug mainly acts on the heart.

Atenolol is includes the drug Atehexal (Hexal AG) and Ateno-isis (Actavis Germany GmbH & Co. KG).

Click here to read more information about the beta blocker Atenolol.

The active ingredient Bisoprolol belongs to the beta-adrenergic receptor blockers and decreases the effect of adrenaline on the heart and is used mainly in hypertension, heart failure and disorders of the cardiovascular system.

Medications containing Bisobeta (beta pharm Arzneimittel GmbH) and Bisogamma (Wörwag Pharma GmbH & Co. KG).

Click here to read further information about the major beta blocker Bisoprolol.

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Drugs in hypertension - beta blockers

Metroprolol is also used for high blood pressure and belongs to the group of receptor blockers.

Metroprolol is very well tolerated, but side effects of overdose include a low heart rate and high blood pressure.

The drug is a selective receptor blocker and prevents the docking of the stress hormone adrenaline on the heart.

Here, the heartbeat remains at a normal level.

Click here to read further information about the beta blocker Metroprolol.

Propranolol - this drug is used for cardiovascular disease and high blood pressure and belongs to the beta-adrenergic receptor blockers.

The beta receptors are blocked by Propranolol and prevents an effect on the heart by adrenaline.

In addition, the active compound is used in the prophylaxis of migraine.

Severity and frequency of attacks can be reduced with regular consumption.

Propranolol is contained in the following medications: Dociteron (Mibe GmbH drugs), Obsidan (Actavis Germany GmbH & Co. KG) and Propra-ratiopharm (ratiopharm GmbH).

Click here to read more information about the beta blocker Propranolol and its use to treat high blood pressure.

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