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Calcium channel blockers as a drug for hypertension

Calcium channel blockers and hypertension

Treating hypertension with calcium channel blockers

How to prevent the disease, and what consequences they may have.

High blood pressure is often mentioned as one of the most dangerous diseases in the world.

Although the name doesn’t protrude panic like the plague or typhus, it kills thousands of us every year. But we are not entirely innocent.

Hypertension a so-called disease of civilization, which means it is in most part a side effect of progress and our modern lifestyle.

Hypertension-promoting factors

The exact mechanism of the disease is not yet clear to the doctors but the risk factors are well known to most people and are usually extremely trivial. They include a lack of exercise, an unhealthy diet, obesity and stress. So it's mostly due to our own bad habits that we get this precarious disease. These problems are often difficult to change, but it is worth it.

Therapy for high blood pressure

Calcium channel blocker used to treat high blood pressure

Calcium channel blockers help with high blood pressure

The doctor can more accurately decide whether acute pharmacological therapy is necessary or whether it is better to wait for the blood pressure to normalise through a healthy lifestyle.

Therapy

The medicines for high blood pressure can be divided according to their effect in the following groups. At this point we are only addressing the calcium channel blocker, further information about the other groups can be found by clicking the links.

1. Calcium channel blockers

2. Angiotensin antagonists

3. Beta-blockers

4. Diuretics (water tablets)

5. ACE inhibitor

6. Renin inhibitors

Calcium channel blockers:

This group of drugs is relates to the blood vessels and muscles.

The more tense the muscle, the closer the blood vessel, which in turn increases the blood pressure.

In order to relax properly, the calcium ions must penetrate through certain channels in the muscle cells. The calcium channel blockers block the channels and thus prevent the penetration of the ions. The result is a fast muscle relaxation and finally a rapid decrease in blood pressure.

Various types of calcium channel blockers

Generally, there are two different types of calcium antagonists (calcium channel blockers), namely the Non-dihydropyridines and the dihydropyridines.

Non-dihydropyridines include:

- diltiazem

- gallopamil

- verapamil

Dihydropyridines include:

- amlodipine

- clevidipine

- felodipine

- isradipine

- lacidipine

- lercanidipine

- Manidipin

- nicardipine

- nifedipine

- nilvadipine

- nimodipine

- nisoldipine

- nitrendipine

The risk of high blood pressure

Get help with hypertension from calcium channel blockers

Calcium channel blockers for hypertension

High blood pressure can damage all major organs. The result of permanent and untreated hypertension is usually a stroke or a heart attack.

In healthy people, the blood pressure is around 120/80 mmHg. This is the optimal value. A blood pressure of 140/90 is high and hypertension is diagnosed.

Pharmacological therapy is applied at the pressure of 170/110 mmHg.

For mild and moderate hypertension, patients are recommended to change their lifestyle and if that doesn’t bring any improvement, the patient will be prescribed medication. According to experts on blood pressure, it is best for each patient to individually assess the different risk factors (such as family history).

Side effects of calcium antagonists

Calcium channel blockers unfortunately have many side effects because of rapid blood pressure changes often occur. Symptoms such as severe headaches, fatigue, dizziness or violent palpitations can occur.

Moreover, in response to the sudden lowering of the blood pressure, the body’s protection mechanism increases the pulse to compensate for the change. Therefore, patients can often have a “scary” time after taking the drug for the first time.

Application of calcium antagonists

Despite these side effects, calcium antagonists are popular in the pharmaceutical market. Their main advantage is their efficiency.

So, although their use as a monotherapy (single drug) is popular, it is still controversial. They are usually used in combination with other substances.

In addition, medical studies have shown that they can be an excellent way to prevent heart attacks.

Here you can read about the calcium antagonist diltiazem and its application in high blood pressure.




Calcium channel blockers for high blood pressure




Various types of calcium channel blockers

In general there are 2 different types of calcium antagonists (calcium channel blockers), namely the non-dihydropyridine and the dihydropyridines.

Non-dihydropyridines are:

- diltiazem
- gallopamil
- verapamil

Dihydropyridines are:

- Amlodipine
- Clevidipine
- Felodipine
- Isradipine
- Lacidipine
- Lercanidipine
- Manidipine
- Nicardipine
- Nifedipine
- Nilvadipine
- Nimodipine
- Nisoldipine
- Nitrendipine




Hypertension and calcium antagonists - a risk




Side effects of calcium channel blockers




What kind of drugs for treating high blood pressure?