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Chlorthalidone with high blood pressure

Chlorthalidone in hypertension

Chlorthalidone is a drug which is used as a remedy for high blood pressure and as a diuretic substance.

The active ingredient belongs to the thiazide diuretics. By itself, this chemical, rinses out through the urine, water retention in the tissue or in combination with other drugs, such as atenolol or metoprolol, and it is used as a means to treat hypertension.

As a single agent, the agent is called Hygroton.

The trade name as a combined preparation with atenolol is called Teneretic mite.

It can be taken in combination with two other drugs, whereby the drug is given the trade name Tri-Normin 25.

Mode of action of chlorthalidone

Chlorthalidone alone is only effective for dewatering, which is why it is used in combination with another substances to treat high blood pressure.

The mixture of this and the substance metoprolol acts by blocking the β-adrenoceptors and the first beta receptors.

It is reduced by the force of contraction and the clout of the heart.

The diuretic chlorthalidone

Chlorthalidone as diuretics in hypertension brings help

This combination is taken orally, by which it is immediately absorbed by the mucous membrane of the intestines. After about 1.5-2 hours almost the entire drug is absorbed. At weaning the dose should be reduced slowly, otherwise it could lead to physical complications.

Side effects

The diuretic chlorthalidone can very quickly have a diuretic effect, causing a frequent urine discharge. It can sometimes cause a ringing in the ears and dizziness, which are associated with fatigue and headaches.

More rarely, nausea, diarrhea and other gastrointestinal complaints can occur. If alcohol is also consumed the side effects may increase again and mild cognitive disturbances can occur which prevent the use of the drug when driving or operating heavy machinery.

Interactions of chlorthalidone

The hypertension drug chlorthalidone acts not only against hypertension, but may also interact with other agents. The reduction of blood pressure is again enhanced when taken simultaneously with certain antidepressants or other hypertensive drugs.

The dosage of insulin and the administration of antibiotics must be adjusted while taking this medicine, as this can lead to further side-effects such as severe nausea.

It can lead to gout-like complications if extra vitamin D is taken, which may have effects on potassium levels.

Anti-inflammatory substances may result in the weakening of the Chlortalidons and thus lead to a higher blood pressure.

Here you can read more about the thiazide diuretics, including chlorthalidone.

Here you can read more about the diuretic eplerenone and its use in high blood pressure.




The diuretic chlorthalidone




Interactions of chlorthalidone






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