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The beta blocker esmolol

The beta blocker esmolol

Solutions for treating high blood pressure: esmolol

The beta-blocker esmolol is often used in emergency medicine for high blood pressure

Esmolol - indispensable in emergency and intensive care

Esmolol or esmolol hydrochloride is one of the beta1-blockers, drugs that inhibit the effect of the stress hormone epinephrine and the neurotransmitter norepinephrine.

It is often used in the acute treatment of heart disease in emergency and intensive care, as it reduces high blood pressure and the heart rate very quickly. It is administered in the form of a bolus injection (intravenous injection) or subcutaneously or intramuscularly.

Spectrum of beta-blocker

The drug belongs to the selective, ultra-short-acting beta-blockers: It lowers the blood pressure within about 2 minutes and has a half-life in the body of about 9 minutes.

To stabilize emergency heart patients, they have to be given different dosages over a course of time.

The main active ingredient of this highly efficient drug is part of the ester functional group.

As infusion of esmolol hydrochloride is available with varying buffer solutions often including sodium hydroxide/hydrochloric acid.

Applications of esmolol

The beta1-blocker is mainly used during and shortly after a heart attack, until the heart rhythm returns to normal. In chronic cardiac arrhythmias, angina pectoris and severe hypertension medical studies have clearly demonstrated the life-prolonging effect of the drug esmolol.

Even patients with heart failure can find a significantly higher life expectancy by the administration of esmolol hydrochloride. Since the beta-blocker leads to a reduction in the blood pressure and better blood flow, it is also highly effective in the treatment of coronary heart disease.

In addition, esmolol is also used to treat hyperthyroidism, tremors, migraines, anxiety and other disorders.

Side effects

Esmolol is well tolerated in general, but with prolonged use can have the same side effects as other beta-blockers.

It should not be administered to patients with bronchial asthma, because it can cause asthma attacks. 

Beta-blockers for high blood pressure

The beta-blocker esmolol is often used for high blood pressure.

Even with concurrent use of calcium channel blockers (to treat hypertension and heart rhythm disorders), it is contraindicated because it can reinforce the effect of the channel blockers.

When taken over a longer period of time, it may cause the patient to have severe fatigue and feel depressed.

Trade names

Esmolol hydrochloride is sold under the name Brevibloc and it many generic brands are also available.

Here you can read more about the beta blocker Levobunolol and its use in hypertension.




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