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The diuretic furosemide

The diuretic furosemide

The diuretic furosemide belongs to the loop diuretics. This group of diuretics is characterized in that it is active in the kidneys at the loop of Henle.

The drug furosemide, chemically known as 4-chloro-2-furfurylamino-5-sulfamoyl-benzoic acid, inhibits a transport protein (Na +-K + -2Cl - symporter) and leads, through the reduction of ion uptake, to a change in the osmotic pressure and increased water excretion.

The amounts of discharged liquid can, with appropriate hydration, be up to 45 litres.

It therefore has a strong diuretic effect which starts after 60 minutes and has a relatively short lifespan of about 6 hours duration.

The indication of furosemide drugs largely coincides with that of other diuretic agents.

They are used for the treatment of edema, especially in acute situations, such as a brain or pulmonary edema.

Diuretics for high blood pressure

Furosemide as diuretics can help with high blood pressure

In hypertension, the diuretic furosemide is used.

Water retention can be treated with medication.

Similarly, one uses it to treat electrolyte disturbances, such as hyperkalaemia.

The use in high blood pressure (technical term: arterial hypertension) is based on the mechanism of action, that a decrease of the volume of blood takes place in the vascular system and there is an increased excretion by the kidneys.

This decrease in volume causes the reduction of blood pressure.

However, fast-acting loop diuretics, are not always the best choice for hypertension. In the case of acutely elevated blood pressure, furosemide is used when there is a possibility of an accompanying pulmonary edema.

For routine treatment of arterial hypertension, Thiazintyp is better.

However, if the drug furosemide is used, the effect of mild to moderate arterial hypertension is good.

Side effects of furosemide

In addition to hypertension, impaired renal function or an edema is possible.

As more electrolytes are discharged via the kidneys in the urine with the increased excretion of urine, then the use of medication for an electrolyte deficiency is contraindicated.

An additional benefit from the increased amount of calcium in the urine is an decreased chance of suffering from kidney stones.

Through often used to lower blood pressure, the use of diuretics and low blood pressure is not recommended. The same applies for the use during lactation or in hepatic coma.

Known side-effects include dehydration if the electrolyte levels are not regularly monitored.

Symptoms include dizziness, headaches and a tendency to collapse. Due to the increased excretion of protons, there may also be a shift in the pH.

Also, hearing loss may occur during treatment, but this is usually ends after a while.

Here you can read more about the diuretic hydrochlorothiazide and its use in high blood pressure.

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