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Lowering blood pressure and irbesartan

Blood pressure lowering and irbesartan

Irbesartan is used for essential hypertension. It is also administered to renal disease patients with hypertension and type 2 diabetes mellitus and diabetic nephropathy.

This cure for high blood pressure comes from one of the group of sartans that binds to AT1 receptors in the blood vessels. Thus, it highlights the effect of endogenous angiotensin II that can cause hypertension.

It causes relaxation and the dilation of blood vessels and lowers blood pressure.

The drug is taken once daily without regard to meals. Since it has a long half-life of 11 to 15 hours meaning that a more frequent administration is unnecessary.

The dosage is usually between 150 and 300mg. The blood pressure medicine is available as a single agent or as a combined preparation with hydrochlorothiazide.

It was initially sold under the trade names Aprovel and Karvea (mono-preparation) as well as under the trade name CoAprovel and Karvezid (combination product).

Irbesartan as a drug

Irbesartan brings quick help to high blood pressure

The combination product is used when irbesartan or hydrochlorothiazide alone do not have sufficient strength to lower the blood pressure. Since Hydrochlorothiazide is a diuretic and therefore belongs to a different type of active ingredient this drug further helps the reduction of the blood pressure.

The manufacturer of the original medicine is Sanofi-Aventis. The pharmaceutical company received approval in 1997 for Aprovel and was awarded a license for the distribution of Karvea by Bristol-Myers Squibb.

Since the patent has expired, Irbesartan is sold as a generic drug by various manufacturers, such as Hexal Pharma GmbH, 1A Pharma GmbH, Stada Pharm GmbH and numerous other generic manufacturers.

Side effects include headaches, dizziness, fatigue, dizziness, a rapid heartbeat, chest pain, coughing, indigestion and lower blood pressure can occur when taking irbesartan.

In rare cases, hypersensitivity reactions and liver and kidney disorders were observed.

Risks of irbesartan

Blood pressure medicines should not be taken in case of hypersensitivity, in hereditary angioedema or if you have a severe hepatic impairment.

The risk of hyperkalaemia may be increased, if potassium salts and sea salts are ingested. Since the drug is teratogenic, it should not be administered during pregnancy.

Relevant drug interactions could not be determined yet, but are also not completely ruled out. Taking it with lithium or NSAIDs is not recommended.

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