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Metoprolol in hypertension therapy

Metoprolol in hypertension therapy

Metoprolol is a drug that is used in the treatment of hypertension, coronary heart disease, and in the the acute treatment of heart attacks. Metoprolol is a selective beta1-blocker that blocks the adrenergic receptors.

Therapies for high blood pressure

Metoprolol belongs to a group of five different operating means for blood pressure.

Diuretics such as torasemide reduce the volume load of the heart in which they support the excretion of urine. ACE inhibitors such as ramipril reduce the angiotensin-converting enzyme.

The absence of the enzyme expands blood vessels and promotes diuresis.

The angiotensin-receptor blockers act as ACE inhibitors. Selective beta blockers such as metoprolol reduce the heart rate and lower blood pressure.

Calcium channel blockers block the calcium channels in the heart and expand the blood vessels, reduce the heart rate and thus reduce hypertension.

Metoprolol and its application

Metoprolol as a beta-blocker brings help with hypertension

The beta-blocker Metoprolol is often used for high blood pressure

The use of selective beta-blockers in drug therapy occurs after three treatments:

  • Beta-blockers are the first drug used. If this doesn’t work well, then gradually more drugs are used.
  • With high blood pressure or an underlying disease, a combination therapy is applied. At the start of therapy, two drugs are used to combat hypertension.

For example, the ACE inhibitor ramipril and the beta-blocker metoprolol.

  • If this doesn’t work, then the high blood pressure is combated by using various drugs until the blood pressure is lowered.

You should not use too many drugs. Therefore, the selection of the drug and the therapy for hypertension depends on how the patient responds.

The mechanism of action of metoprolol

The selective beta blocker blocks the beta1-Adrenorezptoren. They are found in the heart tissue, the atria, the AV node and the ventricular musculature and the coronary arteries.

Stimulation of beta-adrenoreceptors does not occur. The membrane-stabilizing force is only small.

The drug metoprolol for high blood pressure affects the uptake and distribution in the body.

In the gastrointestinal tract, the drug metoprolol is added and introduced into the liver and it affects the metabolism. The maximum of the active compound is reached after 1.5 to 2 hours.

The plasma protein is bound to 12%. The drug is eliminated. The half-life of the plasma is 3-5 hours. To avoid a strong reaction cycle, the drug metoprolol should be discontinued slowly.

Administration of metoprolol

Metoprolol is often used against hypertension

Metoprolol is the most commonly prescribed beta-blocker for high blood pressure

The product is offered as metoprolol succinate, metoprolol tartrate or metoprolol fumarate in tablet form of different strengths. It may be a single preparation or a combination preparation with hydrochlorothiazide. Also, the drug can be taken in intravenous form.

So that a particularly uniform plasma level is reached, the active substance is released at a constant rate. Metoprolol is used for high blood pressure.

The selective beta-blocker metoprolol reached 900 million average daily doses in 2012, and it is the most common drug for hypertension in the world. 

Here you can read more about the beta-blocker nebivolol and its use in hypertension.




Metoprolol and its application




The mechanism of action of metoprolol




Administration of metoprolol







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