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High blood pressure - Nimodipine

High blood pressure - nimodipine

Nimodipine belongs to the chemical group of the 1,4-dihydropyridines, and is a drug which is used for the blocking of calcium channels. The use of this substance is mainly to treat high blood pressure as a calcium channel blocker, but it is also used as a treatment for circulatory disorders in the brain or to prevent vascular spasms in the brain.

It is orally taken when used as a remedy for hypertension, it reaches is full effect after around two hours.

The common trade name for this ingredient as a drug is Nimotop.

Mode of action of nimodipine

Nimodipine acts as a blocker of calcium channels in the central nervous system, since it is of the nifedipine type. Preferably, this blocker exerts its effect in cerebral vessels.

In general, it can be used to treat high blood pressure and to stabilize the blood pressure. It works quickly across the blood-brain barrier and is absorbed from the small intestine, which is why it can quickly develop its full effect.

Side effects of nimodipine

Common side effects include a strong feeling of warmth and redness with concurrent headaches. It can occasionally cause fatigue, dizziness, a slight numbness and sensory disturbances. It may also be accompanied with nausea and some other gastrointestinal complaints.

Ankle swelling and water retention are observed more frequently. Very rarely there may be a reduction in renal function. It is also possible that the patient may suffer a heart attack, but this is rarely the case and should not be ignored.

Interactions

Blood pressure is again lowered, when nimodipine is taken with alcohol, antidepressants or drainage capsules. In combination with the substance diltiazem, it may cause an enhancement of the calcium channel blocker, which can quickly produce hypertension again.

The calcium channel blocker nimodipine

The concomitant use of digoxin, theophylline, cyclosporin or cephalosporins may cause an increase in side effects.

It can also lead to a sharp drop in blood pressure when antacids are used.

The effect is also reduced when taken in combination with nitrates and it may lead to changes in the heart rate.

It should not be taken at the same as narcotics, as it can also lead to total a very strong decrease in blood pressure and thus increase more side effects, such as fatigue again.

Here you can read more about the calcium antagonist nisoldipine and its application in high blood pressure.




Side effects of nimodipine




The calcium channel blocker nimodipine in hypertension




Various types of calcium channel blockers

In general there are 2 different types of calcium antagonists (calcium channel blockers), namely the non-dihydropyridine and the dihydropyridines.

Non-dihydropyridines are:

- diltiazem
gallopamil
verapamil

Dihydropyridines are:

Amlodipine
Clevidipine
- Felodipine
- Isradipine
- Lacidipine
- Lercanidipine
Manidipine
Nicardipine
Nifedipine
Nilvadipine
Nimodipine
Nisoldipine
Nitrendipine




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