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Nisoldipine with high blood pressure

Nisoldipine in hypertension

The drug nisoldipine is a blood pressure medicine from the family of calcium channel blockers, and it is used on patients with essential hypertension (hypertension without organic causes). Likewise, it is used for heart disease which is associated with an insufficient oxygen supply to the heart (cardiac insufficiency).

The active ingredient is proven to reduce high blood pressure and oxygen consumption of the heart.

Similarly, the arteries and veins are extended in order to ensure a better blood flow.

The effect is to block the calcium channels in the walls of the vascular musculature. This prevents the influx of calcium into the muscle, so the muscle relaxes and the blood vessels widen. Therefore, hypertension is prevented, and there is a lowering of blood pressure.

The calcium channel blocker nisoldipine

Nisoldipine as a calcium antagonist for hypertension

Calcium antagonists such as nisoldipine are used in hypertension

In addition, the drug nisoldipine extends blood vessels that supply the heart with oxygen. Thus, heart pain, caused by an anomaly in cramped or constricted blood vessels in the heart, can be reduced.

The drug is immediately and almost completely absorbed and degraded and starts to work after only 30 minutes.

In medicines it is therefore often included in retarded form. These prolonged-release formulations delay the release of the drug over a longer period of time.

Wherein a supply of the drug to the body is guaranteed and maintained over a longer period, the blood pressure almost continuously stays at a constant normal level.

Interactions of nisoldipine

A contraindication to the administration of this drug is when there is a known hypersensitivity to the preparation or calcium channel blockers.

Nisoldipine should not be given when the patient is in a state of shock, suffering from a significantly low blood pressure or where there is a high degree of narrowing of the aorta.

Drugs with the drug nisoldipine should not be taken with grapefruit juice, as this prevents the breakdown in the body and unnecessarily increases the blood pressure lowering effect of the substance.

Possible side effects show up in the form of blood spurts with heat sensation, headaches, fatigue, tachycardia and palpitations.

Rare or very rare side effects may occur in the form of nausea, diarrhea, a rise in blood sugar levels or gingival overgrowth.

In some cases allergic skin reactions, local muscle pain or tremors may occur.

Nisoldipine in hypertension

The calcium channel blocker shows various interactions. With a simultaneous intake of antihypertensive agents, beta-blockers, tricyclic antidepressants, diuretics and antiulcer agents (e.g. cimetidine), there is a greater effect on the lowering of the blood pressure. Similarly, the simultaneous use with prazosin can lead to a particularly sharp drop in blood pressure.

Muscle relaxants work well with the long-term use of nisoldipine.

Other side effects and interactions can be found on the package insert of each drug.

Here you can read more about the calcium antagonist nitrendipine and its application in high blood pressure.




The calcium channel blocker nisoldipine




Interactions of nisoldipine




Nisoldipine in hypertension




Various types of calcium channel blockers

In general there are 2 different types of calcium antagonists (calcium channel blockers), namely the non-dihydropyridine and the dihydropyridines.

Non-dihydropyridines are:

- diltiazem
gallopamil
verapamil

Dihydropyridines are:

Amlodipine
Clevidipine
- Felodipine
- Isradipine
- Lacidipine
- Lercanidipine
Manidipine
Nicardipine
Nifedipine
Nilvadipine
Nimodipine
Nisoldipine
Nitrendipine




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