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Hypertension - perindopril as ACE inhibitors

Perindopril belongs to the group of ACE inhibitors and it has diuretic and antihypertensive properties.

In addition, arteriosclerosis is treated with this drug.

Find out more about the ACE inhibitor

The angiotensin converting enzyme (ACE) is inhibited by the drug and perindopril is used to treat heart failure and high blood pressure.

Also, it is often administered in combination with diuretics.

Common side effects include severe lowering of blood pressure and a dry cough (ACE inhibitor cough).

Perindopril holds back potassium in the body, which must be taken into account during the treatment.

The active substance in perindopril is a prodrug.



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Perindopril against high blood pressure

Hypertension need not be - ACE inhibitor perindopril
Perindopril in hypertension

In 2013, the first generic product containing 5 or 10 mg of Perindopril was released.

Furthermore, it is often taken as a combination with indapamide or amlodipine.

Usually the drug is taken in the morning, during or before breakfast.

It is taken orally.

Which diseases are approved with perindopril?

The active ingredient is helpful in the following diseases: heart failure, stable coronary heart disease (combined with indapamide), arterial high blood pressure (hypertension) and the hardening of the arteries.

Find out more about hardening of the arteries (atherosclerosis)

A hardening of the arteries indicates a systemic disease of the arteries.

It leads to deposits of thrombi, blood fats, connective tissue and calcium (in small amounts) in the vessel walls.

Risk factors for atherosclerosis include age, smoking, obesity, diabetes mellitus, stress, gout and high blood pressure.




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When should the drug not be taken ?

The ACE inhibitors should not be taken for renal failure, ACE inhibitor sensitivity, during pregnancy and during lactation.

What is there to consider?

One must note that diuretics and other antihypertensive agents can lower blood pressure.

Furthermore, potassium and diuretics - which are potassium-saving - especially in renal insufficiency, can lead to hyperkalaemia.

The lithium elimination may be reduced by perindopril, with a combination with insulin and antidiabetic drugs which can cause hypoglycaemia.

Side effects

Common side effects are low blood pressure, a dry cough, dizziness, headaches, weakness and sensory disturbances.

Furthermore, it can lead to tinnitus, balance problems, skin rashes and taste disorders.

Other possible side effects include blurred vision, hypersensitivity reactions, upset stomachs, respiratory and renal dysfunction.




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ACE inhibitors in an overview

Other drugs in this group are listed here alphabetically. 

For more information, simply click on the link

Benazepril (Lotensin)

Captopril (Capoten)

Cilazapril

Enalapril (Vasotec)

Fosinopril (Monopril)

Lisinopril (Prinivil, Zestril)

Moexipril

Perindopril

Quinapril (Accupril)

Ramipril (Altace)

Spirapril

Trandolapril

Zofrenopril

Also note that the ACE inhibitors are often used in combination with other blood pressure lowering drugs. 

Here you read about the so-called combination therapy in hypertension.


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