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The beta blocker pindolol in use against hypertension

The beta-blocker pindolol

Pindolol belongs to the group of non-selective beta-adrenergic antagonists and is used to treat cardiovascular diseases such as hypertension, high blood pressure, heart rhythm disturbances, heart pain (angina pectoris), glaucoma and migraines.

It affects both beta-1 receptors in the heart, as well as beta-2 receptors located in the smooth muscle of the bronchi, uterus and blood vessels.

By blocking the beta-1 receptors, the effect of hormones epinephrine and norepinephrine is inhibited, resulting in a reduction in heart rate and blood pressure.

Due to the binding with beta-2 receptors in the juxtaglomerular apparatus of the kidney, the production of renin is inhibited and hence the production of peptide hormones, angiotensin 2 and aldosterone, resulting in the inhibition of vasoconstriction and water retention.

This results in a reduction in intravascular volume at both blood pressure and heart rate, as well as the burden on the heart to be reduced. Pindolol can be taken intravenously and orally.

High blood pressure and pindolol

Pindolol as beta blockers brings help with high blood pressure

Pindolol as beta blockers for high blood pressure patients

In the form of drops, the drug may be used on the eye in order to reduce the production of aqueous humor in the and reduce intraocular pressure.

The metabolism takes place in the liver and the elimination in the kidneys. Pindolol should not be taken with hypotension, bradycardia, asthma, diabetes mellitus, hyperthyroidism, heart failure and disorders of the conduction system.

The side effects may vary depending on the dosage form of the drug. Common side effects include diarrhoea, constipation, vomiting, nausea, allergic reactions, fatigue, dizziness, increased sweating, nervousness, insomnia and depression.

Occasional side effects include muscle weakness, muscle cramps, bradycardia, dry mouth, conjunctivitis, and oral dryness. Rarely, it could lead to fainting, palpitations, heart block, shortness of breath, worsening of diabetes and erectile dysfunction.

Very rarely it could cause a worsening of pre-existing psoriasis, elevated liver function tests, blurred vision and conjunctivitis. The interactions vary depending on the form of drug intake.

Risks of pindolol

The intake of insulin, which is taken for the treatment of diabetes can intensify and prolong the effect of beta blockers.

In addition, the symptoms of heart palpitations and tremors can no longer serve as identification of such a disease. When co-administered with other drugs that are indicated for the reduction of hypertension and high blood pressure, it may result in a rise in blood pressure.

This could cause disturbances of consciousness, pulsating headaches, dizziness and blurred vision. The same applies to antiarrhythmic drugs, calcium channel blockers such as verapamil, diuretics, narcotics, barbiturates and vasodilators.

Here you can read more about the beta blocker propranolol and its use for high blood pressure.

High blood pressure and pindolol

Risks of the beta blocker pindolol

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