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Sartans and high blood pressure

High blood pressure often goes unnoticed for a long time, although the consequences are far-reaching and dangerous. The treatment should not be left to chance.

A relatively new option for therapy are sartans (also: AT1 antagonist, AT1 receptor antagonists A2A). They are used as antihypertensive medicines used to treat high blood pressure (hypertension), heart failure, and for the treatment of kidney disease in diabetics.

They are often used after heart attacks.

Sartans are similar to ACE-inhibitors and the mechanism of action is similar: Like the ACE inhibitors, they reduce the blood pressure naturally by using a vasoconstrictor angiotensin II (AT-II).

In principle, it is these competitive inhibitors, which act selectively on the AT-II receptor. Thereby it can inhibit the cardiovascular effects of angiotensin II, and therefore angiotensin II reduces the blood pressure.

Vasodilators can resolve one of the most common causes of hypertension: The vasoconstriction.

Operation of the sartans

Sartans are often used for high blood pressure

Furthermore, the agents have an anti-hypertrophic effect, so they help against the enlargement of organs and thus have a positive effect on blood pressure. They are also diuretic and natriuretic, which means that they increase the excretion of sodium ions.

In addition, they have a potassium-retaining influence on the body. They are also used to retain the potassium in the body.

Sartans are particularly suitable for those hypertensive patients who cannot tolerate ACE inhibitors.

Approved drugs include Azilsartanmedoxomil, candesartan, losartan, eprosartan, irbesartan, olmesartan, telmisartan and valsartan.

Headaches, dizziness and fatigue are among the more common side effects of these drugs.

They should not be used if the patient has renal artery stenosis or renal insufficiency, and if they have liver dysfunction or heart disease.

Furthermore sartans shouldn’t be used if the patient is suffering from so-called Conn's syndrome, or hypertrophic cardiomyopathy.

They must also not be taken during pregnancy or lactation. Find out what medications are allowed during pregnancy.

Sartans - antagonists

Since both sartans and ACE inhibitors have beneficial effects in hypertension, the research for a long time assumed that the two agents should be taken as a combination to achieve the best results.

Several studies, however, showed that this can have adverse reactions. In addition, the protective function of the kidney when taking the two drugs is lost.

In addition, since blood pressure medications were thought to cause cancer, many studies were carried out. However, this could not be confirmed. Also note that the AT1 antagonists have only been on the market since 1998. This means that they are under patent protection, and thus are very expensive.

The acting antihypertensive agents are available from various manufacturers. Losartan Hexal and Sandoz have a defined daily dose (DDD) of 50mg.

The eprosartan Ct ratio is 600mg and valsartan Diovan 80mg. Irbesartan, Aprovel has a DDD of 150 mg, Candesartan Atacand 8mg, Telmisartan Micardis 40mg and Olmetec Olmesartan is 20mg.

Your physician will decide which medication for high blood pressure is the most appropriate based on individual circumstances.

Find out everything about the Sartan Azilsartanmedoxomil here.

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