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High blood pressure and spironolacton

High blood pressure and spironolactone

The blood pressure can be selectively reduced. Flows per minute over 1 litre of blood to our kidneys are largely filtered out. Complex exchange and control mechanisms ensure that unnecessary or harmful substances are excreted.

In the urinary bladder degradation products of metabolism, salts and excess water accumulate during this process.

In this case, the hormone aldosterone which is produced in the adrenal cortex plays an important role in regulation of water and the mineral balance. It holds back the sodium in the body and on the other hand promotes the excretion of potassium. Spironolactone is from the group of potassium-sparing diuretics and is used as a dehydrating agent.

It achieves exactly the opposite effect of aldosterone: It promotes the excretion of sodium and potassium stays in the body.

The diuretic spironolactone

Spironolactone diuretics used for hypertension

With high blood pressure and hypertension doctors prescribe the diuretic spironolactone

Due to the displacement of the hormone aldosterone from its binding sites in the cell, water excretion is promoted by the kidney via the ingestion of the drug, and thus inhibits the action of aldosterone.

Since the sodium is reduced by increasing the intake, more water is excreted as sodium has the property to bind with water.

This means that the amount of urine increases and the amount of blood is reduced by the water loss.

The heart can therefore be relieved in this way and the high blood pressure is counteracted. Water, which is converted from the blood vessels into the tissue, is simply withdrawn. Edema are flushed and potassium is retained in the body.

How high blood pressure can be lowered selectively

Lowering the blood pressure of hypertensive patients to reasonable values tends ​​to be particularly difficult.

Diuretics help with hypertension

High blood pressure is above the value of 140/90 mmHg (guidelines of the European Society of Hypertension (ESH)). This reduction of high blood pressure can be relatively easily achieved if there are no secondary problems. Higher monotherapy dosages with additional spironolactone will start to work early.

There are low to moderate-dose combination therapies recommended that promise fewer side-effects and better success.

One speaks of a therapy-resistant hypertension when the maximum dose of the triple combination of drugs shows no improvement in blood pressure results.

Due to lack of studies, the physician can then only try to reduce high blood pressure by individual exploratory strategies. So they attempt to add a supplement of 25 mg spironolactone to triple combination therapy.

Spironolactone

Medication for hypertension

Spironolactone is a drug that has now been used for over 50 years to treat high blood pressure. Recently, it was also found that it promotes the heart filling phase of patients suffering from diastolic heart failure.

Despite these promising results, no influence on the quality of life is known.

Also for patients suffering from renal insufficiency or proteinuria, or those that have suffered from a stroke in the past can see results from this drug.

Here you can read more about the diuretics thiazide and their use in high blood pressure.




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