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German doctors have remedies against high blood pressure


Trandolapril as ACE inhibitors in hypertension

Trandolapril is an ACE inhibitor and is used for high blood pressure (hypertension) and heart failure as well as in pathological vascular changes in the kidneys (due to diabetes).

Trandolapril can be used both individually and also in combination with other agents for high blood pressure reduction (combination therapy) and is available on prescription.

It is often used with diuretics and other calcium channel inhibitors.

ACE stands for angiotensin-converting enzymes, i.e. enzymes that inhibit the conversion angiotensin.

Trandolapril works by influencing the renin produced in the kidney that is responsible for blood pressure regulation and water balance.

Trandolapril prevents the conversion of angiotensin I to angiotensin II.

Trandolapril is a so-called prodrug and is taken orally.



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The ACE inhibitor Trandolapril in hypertension
Trandolopril in hypertension

Side effects of Trandolapril

Side effects include bronchitis, coughing, visual disturbances, weakness, dizziness, nausea, indigestion, headaches, drowsiness and impaired renal function and renal failure.

In some rare cases there is a strong reduction of blood pressure leading to low blood pressure, a high protein excretion in the urine, difficulty in breathing, a runny nose, sinus infections, inflammations of the pancreas, allergic reactions like skin itching and eczema.




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The ACE inhibitor Trandolapril for hypertension

Very rarely, people can faint, lose consciousness, suffer from depression, sleep disorders, blurred vision, and rhinitis.

Anaemia and a reduction of haemoglobin will lead to a decrease in the platelets.

Rashes such as hives can also occur.

Moreover cardiac arrhythmias, strokes, acute renal failure, liver disorders, intestinal obstruction, hair loss, peeling skin, inflammation of the oral cavity, inflammation of the liver, joint pain, massive reduction in blood pressure, gall bladder infections can also occur.

In about 5% of all treatment cases, treatment with Trandolapril should be discontinued.

Contraindications

Trandolapril may not be used for any problems concerning the kidneys, such as a narrowing of the renal arteries or in dialysis patients.

Drug

- Udrik (capsules of 0.5, 1 and 2 mg)

 

 




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ACE inhibitors in an overview

Other drugs in this group are listed here alphabetically. 

For more information, simply click on the link

Benazepril (Lotensin)

Captopril (Capoten)

Cilazapril

Enalapril (Vasotec)

Fosinopril (Monopril)

Lisinopril (Prinivil, Zestril)

Moexipril

Perindopril

Quinapril (Accupril)

Ramipril (Altace)

Spirapril

Trandolapril

Zofrenopril

Also note that the ACE inhibitors are often used in combination with other blood pressure lowering drugs. 

Here you read about the so-called combination therapy in hypertension.


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